Unfortunately, the necessary research has not been conducted to give anyone solid advice about the safety of taking psychedelics with all prescription medications. However, it is known that antidepressants can significantly reduce the effects of microdosing.
There is also evidence that combining psilocybin with lithium can lead to heart problems. Even though no dangerous interactions have been reported, we certainly do not recommend that you microdose in combination with any other recreational drugs, including alcohol.
To be extra safe, make sure you check with your physician before microdosing psilocybin mushrooms.